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At the completion of this program, you should be able to:

1. Identify mechanisms of the first line of immune defense.
2. List several types of leukocytes and their functions.
3. Explain the function of immunological memory.
4. Describe the three main components of the inflammatory response.
5. Summarize inflammatory response to major illness.
6. Discuss patient care needs associated with selected immune disorders.

1. Immunity: Overview and Definitions
1. Self versus nonself
2. Role of antigens (Immunogens)
2. The Immune System
1. Lymphoid (Immune) system
2. Structure and function
3. Biological role of C system
3. Major Histocompatibility Complex
1. Classes of MHC antigens
2. Role of MHC antigens in transplants and autoimmunity
3. Autoimmunity
4. The Immune Response: Putting it all together
1. Afferent limb
2. Efferent limbs
3. Goal of afferent and efferent is to react with the immunogen and render it inactive
4. Primary response
5. Secondary responses
6. Types of immunity
7. Hypersensitivity reactions
8. Immunodeficiency disorders
5. Human Immunodeficiency Virus (HIV) Organ-Specific Autoimmune Disease
1. Idiopathic thrombocytopenia purpura (ITP)
2. Multiple Sclerosis
3. Guillain-Barré Syndrome
4. Myasthenia Gravis
5. Rheumatic fever
6. Addison’s disease
7. Type I Diabetes Mellitus
8. Goodpasture syndrome
6. Systemic Autoimmune Disease
1. Systemic Lupus Erythematosus
2. Rheumatoid Arthritis
3. Progressive Systemic
4. Sclerosis (scleroderma)
7. Serum Sickness
1. Exposure to penicillin and sulfonamides
8. ABO Blood Group Antigens
1. Blood typing
2. Rh factor
9. Diagnostic Tests
1. Urine studies
2. Radioisotope studies
3. CT and MRI
4. Biopsies
5. Laboratory studies
10. Inflammatory Reaction
1. Gross features of acute inflammation
2. Fluid aspects of inflammation
3. Cellular aspects of inflammation
4. Mediation of inflammation
5. Types of leukocytes
11. Patterns of Inflammation
1. Acute
2. Chronic
3. Noncellular exudates
4. Cellular exudates
12. Factors Affecting Inflammation and Healing
1. Impaired circulation
2. Decreased leukocytes in the circulating blood
3. Drug inhibitory effects
4. Malnourishment
5. Poor approximation of wound edges
13. Shock and Multi-organ Dysfunction
1. Definitions (Exhibit A)
2. Stages of shock
3. Treatment measures for shock
14. Antibiotic-Resistant Organisms
1. Organisms develop resistance to classic agents and newer agents
2. Genetic and biochemical mutations to evade pharmacology
3. Inappropriate use of antibiotic is a major factor contributing to resistance

Angelica Dizon, MD, MSN, MBA-HCM, BSN, RN, NP-C,is a physician, advanced care practitioner and a registered nurse, with more than two decades of experience in clinical practice. Angelica serves as the director of clinical services in one of the leading home healthcare agencies in Maryland. She has extensive past experiences both in the acute care and long-term care settings as well. Her diverse experiences provide her with unique perspectives on the importance of an in-depth understanding of pathophysiology. As a clinician, she sees complicated patient cases that require a keen understanding of overlapping disease processes. Angelica enjoys sharing her expertise and excels at putting complex topics in to a plain English approach. As such, she is a sought-after presenter, sharing her vast knowledge with experienced interdisciplinary audiences across the country. Disclosures:

Financial: Angelica F. Dizon is a faculty member for Radians College. She receives a speaking honorarium from PESI, Inc.

Nonfinancial: Angelica F. Dizon has no relevant nonfinancial relationships to disclose.

For U.S. and Canadian customers, CE is available for $20 USD per participant. International CE rates may vary; please contact our Customer Service at 1-800-844-8260 for more details.

Listed below are the continuing education credit(s) currently available for this non-interactive self-study package. Please note, your state licensing board dictates whether self study is an acceptable form of continuing education. Please refer to your state rules and regulations.

Certificates of Successful Completion will be emailed, faxed or mailed to participants completing the post-test/evaluation and paying the CE fee.

**Materials that are included in this course may include interventions and modalities that are beyond the authorized practice of mental health professionals. As a licensed professional, you are responsible for reviewing the scope of practice, including activities that are defined in law as beyond the boundaries of practice in accordance with and in compliance with your professions standards.

All members of the PESI, Inc. planning committee have provided disclosures of financial relationships with ineligible organizations and any relevant non-financial relationships prior to planning content for this activity. None of the committee members had relevant financial relationships with ineligible companies or other potentially biasing relationships to disclose to learners. For speaker disclosures, please see the faculty biography.

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Nurses/Nurse Practitioners/Clinical Nurse Specialists - Credit Expired: 1/14/2020
No CE available for this board.

California Nurses: PESI, Inc. is a provider approved by the California Board of Registered Nursing, Provider #:17118 for 6.0 self-study contact hours.

You will need to provide your license number to PESI. PESI must have this number on file in order for your hours to be valid.

Florida Nurses: PESI, Inc. is an approved provider by the Florida Board of Nursing. Provider #: FBN2858. These materials qualify for 6.0 self-study contact hours.

Iowa Nurses: PESI, Inc. is an approved provider by the Iowa Board of Nursing. Provider #: 346. Nurses successfully completing these self-study materials will earn 6.3 self-study contact hours.

Copies of the evaluation may be sent to the IBON. You will need to provide your license number to PESI. PESI must have this number on file in order for your hours to be valid.

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Other Professions
This self-study activity qualifies for 6.25 clock hours of instructional content as required by many national, state and local licensing boards and professional organizations. Retain your certificate of completion and contact your board or organization for specific filing requirements.

Disclaimer: **Information obtained in this course should be used within your scope of practice.
**It is your ethical responsibility to report accurate hours to your licensing board.
**All self-study participants must complete and pass (80% or better) a post-test and evaluation prior to receiving a certificate of completion. If you require a copy of the test/evaluation for CE purposes, please print at the time you take the test. Or you may call our customer service department and a copy of your test/evaluation will be emailed to you. Please allow 30-45 days.

Nurses, Nurse Practitioners, Clinical Nurse Specialists, Physician Assistants